This baseline study could serve as a benchmark for the future sO 2 investigation of retinal macular pathologies. No significant correlation was found between sO 2 and vessel topological features, including length, diameter, and distance to fovea. Marginal correlation was found between venous sO 2 and intraocular pressure (IOP) among eyes. Arteriovenous sO 2 difference was 43.8 ± 9.5 (vol %). The arterial and venous sO 2 from all eyes was 92.1 ± 7.1 (vol %) and 48.4 ± 5.0 (vol %) (mean ± SD), respectively. In this paper, for the first time, we present a baseline study of microvascular oxygen saturation (sO 2) in perifoveal macular region using visible light optical coherence tomography (VIS-OCT) on normal eyes. The parafoveal vessels form the inner retina provide oxygen perfusion, and the measurement of parafoveal oxygen saturation (sO 2) can evaluate macular metabolism and provide pathophysiological insight. The retinal macula is at the center of our visual field, and thus pathological damage in the macula significantly impacts an individual's quality of life. 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.3Department of Ophthalmology, Boston Medical Center, Boston, MA, United States.2School of Mechanical Engineering, Shandong University, Jinan, China.1Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.Fiorello 3, Manishi Desai 3 and Ji Yi 1,4 * Jingyu Wang 1, Weiye Song 2,3, Natalie Sadlak 3, Marissa G.
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